Submitting a research manuscript is a tedious and anxiety-ridden process. It is by no means easy, user-friendly, or logical. I have to make a judicious effort to remember the email address, ID, password, and contact information for each submission at any time. You MUST do this, because editors and reviewers will NOT do it for you.
Upon rejection (and believe me, it is coming), you then have to completely reformat your manuscript with font and boldface changes and writing styles to meet the requisite needs of the new journal. You do this numerous times at the expense of the Impact Factor just to get published...pretty soon, what you ended with is nothing like what you started with, some months or years ago. It's no longer an original thought, but a mish-mash of editorial comments. What is one to do?!
1. First and foremost, follow EXACTLY what the "Guideline for Authors" section tells you to do. Because top-tier journals receive many manuscripts, the author guidelines are an easy way to "weed out" manuscripts. ONE simple mistake in a citation or subheading, and they will reject it or send it back for revisions. You may have to COMPLETELY revamp the structure and writing style of the paper, but at least you have the body of the manuscript put together!
2. Also, the editors may have good ideas on how to make your paper better. If you get a rejection, integrate any pertinent changes into your manuscript. However, if you can tell that the reviewer barely read the manuscript (if at all) and gave you superfluous remarks, then you do not want to submit to that publication anyways.
3. DO NOT GIVE UP! Keep submitting your work. Do not every give up on your manuscript. If it is rejected ten times, make changes and revisions, and then send it in an eleventh time. Check the "Information for Authors" section of each publication and make sure that the journal is focused on the correct audience.
4. Feel free to give the editors of the publication of interest an email or call. Ask if they would be interested in the study you are going to submit and if not, do they have any ideas for other potential publications? And go ahead and feel free to email them when you do not hear back from them, it is their job to get back to you.