In relation to the methodological rigor, heterogeneity of effect, funnel plot, and pooled treatment effects from the article that has been critically appraised, ask these questions when making an applied clinical decision based on systematic review evidence:
1. Is the patient so different from those in the study that its results cannot apply?
2. Is the treatment feasible in the current clinical setting?
3. What are the patient's potential benefits and harms from the therapy?
1. Is the patient so different from those in the study that its results cannot apply?
2. Is the treatment feasible in the current clinical setting?
3. What are the patient's potential benefits and harms from the therapy?
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