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Applying clinical practice guideline evidence

Assess treatment validity, collective beliefs and values, opportunity costs, and implementation barriers

In relation to the clinical practice guideline that has been critically appraised, ask these questions when making an applied clinical decision based on clinical practice guideline evidence:

1. Is the burden of illness frequency in the community, or the patient's pre-test probability or expected event rate, too low to warrant implementation?

2. Are the beliefs and values of the community and the patients compatible with the guideline?

3. Would the opportunity cost of implementing the guideline constitute a bad bargain in terms of the resources needed?

4. Are the geographic, organizational, traditional, authoritarian, legal, or behavioral barriers so high that it is not worth trying to overcome them?

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Assessing Evidence-Based Practice
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There are five considerations taken when applying clinical practice guideline evidence: The burden of illness in the community, the beliefs and values of the community and patients, the opportunity cost of guideline implementation, overcoming barriers, and the harms and benefits of the practice guideline.

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